ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner
H Takatsu, K Baba, T Shima, H Umino, U Kato… - Journal of Biological …, 2011 - ASBMB
Type IV P-type ATPases (P4-ATPases) are putative phospholipid flippases that translocate
phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and
are believed to function in complex with CDC50 proteins. In Saccharomyces cerevisiae, five
P4-ATPases are localized to specific cellular compartments and are required for vesicle-
mediated protein transport from these compartments, suggesting a role for phospholipid
translocation in vesicular transport. The human genome encodes 14 P4-ATPases and three …
phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and
are believed to function in complex with CDC50 proteins. In Saccharomyces cerevisiae, five
P4-ATPases are localized to specific cellular compartments and are required for vesicle-
mediated protein transport from these compartments, suggesting a role for phospholipid
translocation in vesicular transport. The human genome encodes 14 P4-ATPases and three …
