[HTML][HTML] Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation
A Selvaraj, R Prywes - Journal of Biological Chemistry, 2003 - ASBMB
Serum response factor (SRF) is required for the expression of a wide variety of muscle-
specific genes that are expressed upon differentiation and is thus required for both striated
and smooth muscle differentiation in addition to its role in regulating growth factor-inducible
genes. A heart and smooth muscle-specific SRF co-activator, myocardin, has been shown to
be required for cardiac development and smooth muscle differentiation. However, no such
co-factors of SRF have been identified in the skeletal myogenic differentiation program …
specific genes that are expressed upon differentiation and is thus required for both striated
and smooth muscle differentiation in addition to its role in regulating growth factor-inducible
genes. A heart and smooth muscle-specific SRF co-activator, myocardin, has been shown to
be required for cardiac development and smooth muscle differentiation. However, no such
co-factors of SRF have been identified in the skeletal myogenic differentiation program …
