New model of liver regeneration induced through use of vascular endothelial growth factor

G Marino, E Piazzese, S Gruttadauria, G Nicotra… - Transplantation …, 2006 - Elsevier
INTRODUCTION: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen.
The objective of this study was to verify the proregenerative effects of VEGF in an
experimental model of acute liver failure. MATERIALS AND METHODS: Sixty four rats that
underwent intraperitoneal injection of carbon tetrachloride (CCl4) were randomly divided
into two groups: group B animals received intravenous injection of VEGF164 1 hour
following CCl4 poisoning. Group A hosts were untreated. To obtain daily liver function tests …