Seeding specificity in amyloid growth induced by heterologous fibrils
B O'Nuallain, AD Williams, P Westermark… - Journal of Biological …, 2004 - ASBMB
Over residues 15–36, which comprise the H-bonded core of the amyloid fibrils it forms, the
Alzheimer's disease plaque peptide amyloid β (Aβ) possesses a very similar sequence to
that of another short, amyloidogenic peptide, islet amyloid polypeptide (IAPP). Using
elongation rates to quantify seeding efficiency, we inquired into the relationship between
primary sequence similarity and seeding efficiency between Aβ-(1–40) and amyloid fibrils
produced from IAPP as well as other proteins. In both a solution phase and a microtiter plate …
Alzheimer's disease plaque peptide amyloid β (Aβ) possesses a very similar sequence to
that of another short, amyloidogenic peptide, islet amyloid polypeptide (IAPP). Using
elongation rates to quantify seeding efficiency, we inquired into the relationship between
primary sequence similarity and seeding efficiency between Aβ-(1–40) and amyloid fibrils
produced from IAPP as well as other proteins. In both a solution phase and a microtiter plate …
