Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
MH de Borst, MG Vervloet, PM ter Wee… - Journal of the American …, 2011 - journals.lww.com
There is increasingly evidence that the interactions between vitamin D, fibroblast growth
factor 23 (FGF-23), and klotho form an endocrine axis for calcium and phosphate
metabolism, and derangement of this axis contributes to the progression of renal disease.
Several recent studies also demonstrate negative regulation of the renin gene by vitamin D.
In chronic kidney disease (CKD), low levels of calcitriol, due to the loss of 1-alpha
hydroxylase, increase renal renin production. Activation of the renin-angiotensin …
factor 23 (FGF-23), and klotho form an endocrine axis for calcium and phosphate
metabolism, and derangement of this axis contributes to the progression of renal disease.
Several recent studies also demonstrate negative regulation of the renin gene by vitamin D.
In chronic kidney disease (CKD), low levels of calcitriol, due to the loss of 1-alpha
hydroxylase, increase renal renin production. Activation of the renin-angiotensin …
