In recent years a rapidly increasing number of studies has focused on the relationship
between dementia and metabolic disorders such as diabetes, obesity, hypertension, and
dyslipidemia. Etiological heterogeneity and comorbidity pose challenges for determining
relationships among metabolic disorders. The independent and interactive effects of brain
vascular injury and classic pathological agents such as β-amyloid have also proved difficult
to distinguish in human patients, blurring the lines between Alzheimer disease and vascular …