Synthetic magainin analogues with improved antimicrobial activity
HC Chen, JH Brown, JL Morell, CM Huang - Febs Letters, 1988 - Wiley Online Library
HC Chen, JH Brown, JL Morell, CM Huang
Febs Letters, 1988•Wiley Online LibraryBased on modifications to enhance the α‐helical structure of the broad spectrum antibiotic
magainin 2, a series of analogues have been synthesized which display an increase up to
two orders of magnitude in antimicrobial activity and, in the most favorable case, no
appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.
magainin 2, a series of analogues have been synthesized which display an increase up to
two orders of magnitude in antimicrobial activity and, in the most favorable case, no
appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.
Based on modifications to enhance the α‐helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.
Wiley Online Library