Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also
increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition.
Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1
gene within a splice donor region was associated with an altered risk of developing cancer.
Altered RNA splicing caused by this polymorphism gives rise to a variant cyclin D1 isoform
termed cyclin D1b, which has the same N terminus as the canonical cyclin D1a isoform but a …