A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II: purification and amino acid sequence
Y Hiraki, H Inoue, J Kondo, A Kamizono… - Journal of Biological …, 1996 - ASBMB
During endochondral bone formation, cartilage cells show increased matrix synthesis and
rapid proliferation. We found that cartilage matrix contains at least two types of heparin
binding growth-promoting components. One, with a higher affinity to heparin, was identified
as chondromodulin I (Hiraki, Y., Tanaka, H., Inoue, H., Kondo, J., Kamizono, A., and Suzuki,
F.(1991) Biochem. Biophys. Res. Commun. 175, 871-977). In this study, we isolated a novel
growth-promoting component, chondromodulin II, which has a lower heparin affinity, from …
rapid proliferation. We found that cartilage matrix contains at least two types of heparin
binding growth-promoting components. One, with a higher affinity to heparin, was identified
as chondromodulin I (Hiraki, Y., Tanaka, H., Inoue, H., Kondo, J., Kamizono, A., and Suzuki,
F.(1991) Biochem. Biophys. Res. Commun. 175, 871-977). In this study, we isolated a novel
growth-promoting component, chondromodulin II, which has a lower heparin affinity, from …
