Unfolding and refolding of a purified precursor protein during import into isolated mitochondria.
M Eilers, S Hwang, G Schatz - The EMBO journal, 1988 - embopress.org
M Eilers, S Hwang, G Schatz
The EMBO journal, 1988•embopress.orgA purified mitochondrial precursor protein unfolds to a protease‐sensitive conformation at
the surface of isolated mitochondria before being imported into the organelles. This
unfolding is stimulated by a potential across the mitochondrial inner membrane, but does not
require ATP. In contrast, import of the surface‐bound unfolded precursor requires ATP, but
no potential; it is accompanied by a refolding inside the mitochondria.
the surface of isolated mitochondria before being imported into the organelles. This
unfolding is stimulated by a potential across the mitochondrial inner membrane, but does not
require ATP. In contrast, import of the surface‐bound unfolded precursor requires ATP, but
no potential; it is accompanied by a refolding inside the mitochondria.
A purified mitochondrial precursor protein unfolds to a protease‐sensitive conformation at the surface of isolated mitochondria before being imported into the organelles. This unfolding is stimulated by a potential across the mitochondrial inner membrane, but does not require ATP. In contrast, import of the surface‐bound unfolded precursor requires ATP, but no potential; it is accompanied by a refolding inside the mitochondria.
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