Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination
N Mehta, CK Cunningham, P Flynn, J Pepe, S Obaro… - Vaccine, 2010 - Elsevier
N Mehta, CK Cunningham, P Flynn, J Pepe, S Obaro, BG Kapogiannis, J Bethel…
Vaccine, 2010•ElsevierHepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis
B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected
at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The
detection of HBsAb> 10mIU/ml at study week 28 was strongly associated with the detection
of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was
observed. In HIV uninfected individuals, antibody titers> 1000mIU/ml were associated with …
B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected
at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The
detection of HBsAb> 10mIU/ml at study week 28 was strongly associated with the detection
of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was
observed. In HIV uninfected individuals, antibody titers> 1000mIU/ml were associated with …
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
Elsevier
