The mucosal firewalls against commensal intestinal microbes

AJ Macpherson, E Slack, MB Geuking… - Seminars in …, 2009 - Springer
AJ Macpherson, E Slack, MB Geuking, KD McCoy
Seminars in immunopathology, 2009Springer
Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the
constant challenge of small numbers of microbes penetrating the intestinal surface
epithelium, it is very unusual for these organisms to cause disease. In this review article, we
present the different mucosal firewalls that contain and allow mutualism with the intestinal
microbiota.
Abstract
Mammals coexist with an extremely dense microbiota in the lower intestine. Despite the constant challenge of small numbers of microbes penetrating the intestinal surface epithelium, it is very unusual for these organisms to cause disease. In this review article, we present the different mucosal firewalls that contain and allow mutualism with the intestinal microbiota.
Springer