Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia
Z Xu, M Wang, L Wang, Y Wang, X Zhao, Q Rao… - Leukemia research, 2009 - Elsevier
The tuberous sclerosis (TSC) genes, TSC1 and TSC2, encode hamartin and tuberin,
respectively, and are putative tumor suppressor genes that were originally identified due to
their involvement in the inherited autosomal dominant disorder tuberous sclerosis. It has
been elucidated that the two proteins form an intracellular heterodimer participating in
signaling pathway of the mammalian Target of Rapamycin (mTOR). Recent studies showed
that mTOR pathway was frequently activated in blasts from acute myeloid leukemia (AML) …
respectively, and are putative tumor suppressor genes that were originally identified due to
their involvement in the inherited autosomal dominant disorder tuberous sclerosis. It has
been elucidated that the two proteins form an intracellular heterodimer participating in
signaling pathway of the mammalian Target of Rapamycin (mTOR). Recent studies showed
that mTOR pathway was frequently activated in blasts from acute myeloid leukemia (AML) …