[HTML][HTML] PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex
SC Lo, M Hannink - Journal of biological chemistry, 2006 - ASBMB
Keap1 is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase
complex that functions as a sensor for thiol-reactive chemopreventive compounds and
oxidative stress. Inhibition of Keap1-dependent ubiquitination of the bZIP transcription factor
Nrf2 enables Nrf2 to activate a cyto-protective transcriptional program that counters the
damaging effects of oxidative stress. In this report we have identified a member of the
phosphoglycerate mutase family, PGAM5, as a novel substrate for Keap1. The N terminus of …
complex that functions as a sensor for thiol-reactive chemopreventive compounds and
oxidative stress. Inhibition of Keap1-dependent ubiquitination of the bZIP transcription factor
Nrf2 enables Nrf2 to activate a cyto-protective transcriptional program that counters the
damaging effects of oxidative stress. In this report we have identified a member of the
phosphoglycerate mutase family, PGAM5, as a novel substrate for Keap1. The N terminus of …
