Persistent protective effect of heat-killed Escherichia coli producing “engineered,” recombinant peanut proteins in a murine model of peanut allergy
XM Li, K Srivastava, A Grishin, CK Huang… - Journal of allergy and …, 2003 - Elsevier
Background: Peanut allergy (PNA) is a life-threatening food allergy for which there is no
definitive treatment. Objective: We investigated the long-term immunomodulatory effect of
heat-killed Escherichia coli producing engineered (mutated) Ara h1, 2, and 3 (HKE-MP123)
administered rectally (pr) in a murine model of PNA. Methods: Peanut-allergic C3H/HeJ
mice received 0.9 (low dose), 9 (medium dose), or 90 (high dose) μg HKE-MP123 pr, HKE-
containing vector (HKE-V) alone, or vehicle alone (sham) weekly for 3 weeks. Mice were …
definitive treatment. Objective: We investigated the long-term immunomodulatory effect of
heat-killed Escherichia coli producing engineered (mutated) Ara h1, 2, and 3 (HKE-MP123)
administered rectally (pr) in a murine model of PNA. Methods: Peanut-allergic C3H/HeJ
mice received 0.9 (low dose), 9 (medium dose), or 90 (high dose) μg HKE-MP123 pr, HKE-
containing vector (HKE-V) alone, or vehicle alone (sham) weekly for 3 weeks. Mice were …