Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice
BACKGROUND: Agonists of Toll-like receptor 9 have been shown to induce potent TH1-type
immune responses and prevent and reverse ovalbumin-induced TH2-dominant allergic
asthma in mice. OBJECTIVE: We examined oral administration of a synthetic agonist of Toll-
like receptor 9 (immune modulatory oligonucleotide [IMO]) to modulate peanut-induced
allergy in mice. METHODS: In the prevention model mice were sensitized 3 times by means
of oral administration of peanut in the presence or absence of IMO. In a treatment protocol …
immune responses and prevent and reverse ovalbumin-induced TH2-dominant allergic
asthma in mice. OBJECTIVE: We examined oral administration of a synthetic agonist of Toll-
like receptor 9 (immune modulatory oligonucleotide [IMO]) to modulate peanut-induced
allergy in mice. METHODS: In the prevention model mice were sensitized 3 times by means
of oral administration of peanut in the presence or absence of IMO. In a treatment protocol …