Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus
GP Cardona-Gomez, P Mendez… - Molecular Brain …, 2002 - Elsevier
Estradiol and insulin-like growth factor-I (IGF-I) interact in the hypothalamus to regulate
neuronal function, synaptic plasticity and neuroendocrine events. However, the molecular
mechanisms involved in these interactions are still unknown. In the present study, the effect
of estradiol on the signaling pathways of IGF-I receptor has been assessed in the
hypothalamus of young adult ovariectomized rats, using specific antibodies for the
phosphorylated forms of extracellular-signal regulated kinase (ERK) 1 and ERK2 and …
neuronal function, synaptic plasticity and neuroendocrine events. However, the molecular
mechanisms involved in these interactions are still unknown. In the present study, the effect
of estradiol on the signaling pathways of IGF-I receptor has been assessed in the
hypothalamus of young adult ovariectomized rats, using specific antibodies for the
phosphorylated forms of extracellular-signal regulated kinase (ERK) 1 and ERK2 and …
