[HTML][HTML] The role of cation binding in determining substrate selectivity of glutamate transporters
Glutamate transport is coupled to the co-transport of 3Na+ and 1H+ and the countertransport
of 1 K+. However, the mechanism of how this process occurs is not well understood. The
crystal structure of an archaeal homolog of the human glutamate transporters, Glt Ph, has
provided the framework to begin to understand the mechanism of transport. The glutamate
transporter EAAT2 is different from other subtypes in two respects. First, Li+ cannot support
transport by EAAT2, whereas it can support transport by the other excitatory amino acid …
of 1 K+. However, the mechanism of how this process occurs is not well understood. The
crystal structure of an archaeal homolog of the human glutamate transporters, Glt Ph, has
provided the framework to begin to understand the mechanism of transport. The glutamate
transporter EAAT2 is different from other subtypes in two respects. First, Li+ cannot support
transport by EAAT2, whereas it can support transport by the other excitatory amino acid …