Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder
DE Dickel, J Veenstra-VanderWeele… - Archives of general …, 2006 - jamanetwork.com
Context The first 2 independent linkage studies for obsessive-compulsive disorder (OCD)
identified a region on 9p24 with suggestive evidence for linkage. The glutamate transporter
gene solute carrier family 1, member 1 (SLC1A1) is a promising functional candidate in this
region because altered glutamatergic concentrations have been found in the striatum and
anterior cingulate in neuroimaging studies of pediatric OCD. Objective To determine
whether genotypes at polymorphisms in theSLC1A1gene region are associated with early …
identified a region on 9p24 with suggestive evidence for linkage. The glutamate transporter
gene solute carrier family 1, member 1 (SLC1A1) is a promising functional candidate in this
region because altered glutamatergic concentrations have been found in the striatum and
anterior cingulate in neuroimaging studies of pediatric OCD. Objective To determine
whether genotypes at polymorphisms in theSLC1A1gene region are associated with early …