[HTML][HTML] Transforming growth factor-β receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
J Pannu, S Nakerakanti, E Smith, P ten Dijke… - Journal of Biological …, 2007 - ASBMB
The transforming growth factor (TGF)-β/Smad3 signaling pathway is considered a central
mediator of pathological organ fibrosis; however, contribution of Smad2/3-independent TGF-
β signaling has not been fully explored. The present study utilized previously a described
model of scleroderma (SSc) fibrosis based on forced expression of the TGF-βRI
(ALK5)(Pannu, J., Gardner, H., Shearstone, JR, Smith, E., and Trojanowska, M.(2006)
Arthritis Rheum. 54, 3011–3021). This study was aimed at determining the molecular …
mediator of pathological organ fibrosis; however, contribution of Smad2/3-independent TGF-
β signaling has not been fully explored. The present study utilized previously a described
model of scleroderma (SSc) fibrosis based on forced expression of the TGF-βRI
(ALK5)(Pannu, J., Gardner, H., Shearstone, JR, Smith, E., and Trojanowska, M.(2006)
Arthritis Rheum. 54, 3011–3021). This study was aimed at determining the molecular …
