Myeloid cells (granulocytes and monocytes) are derived from multipotent hematopoietic
stem cells. Gene transcription plays a critical role in hematopoietic differentiation. However,
there is no single transcription factor that is expressed exclusively by myeloid cells and that,
alone, acts as a “master” regulator of myeloid fate choice. Rather, myeloid gene expression
is controlled by the combinatorial effects of several key transcription factors. Hematopoiesis
has traditionally been viewed as linear and hierarchical, but there is increasing evidence of …