Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen
WK Bolton, L Chen, T Hellmark… - Journal of the American …, 2005 - journals.lww.com
An amino-terminal region of α 3 chain of type IV collagen noncollagenous domain [α 3 (IV)
NC1] that induces experimental autoimmune glomerulonephritis (EAG) in rats has been
identified. Only recombinant antigens that contain a nine–amino acid (AA) span of α 3 (IV)
NC1, consistent with a T cell epitope, could induce EAG. It was hypothesized that synthetic
peptides of this region should induce EAG. Human and rat peptides of this region were
synthesized and rats were immunized to define the nephritogenic epitope. A 13-AA rat …
NC1] that induces experimental autoimmune glomerulonephritis (EAG) in rats has been
identified. Only recombinant antigens that contain a nine–amino acid (AA) span of α 3 (IV)
NC1, consistent with a T cell epitope, could induce EAG. It was hypothesized that synthetic
peptides of this region should induce EAG. Human and rat peptides of this region were
synthesized and rats were immunized to define the nephritogenic epitope. A 13-AA rat …
