NKT cells and autoimmune diseases: unraveling the complexity
S Miyake, T Yamamura - T cell activation by CD1 and lipid antigens, 2007 - Springer
S Miyake, T Yamamura
T cell activation by CD1 and lipid antigens, 2007•SpringerCD1d-restricted invariant natural killer T (NKT) cells emerge as unique lymphocyte subsets
implicated in the regulation of autoimmunity. Abnormalities in the numbers and functions of
NKT cells have been observed in patients with diverse autoimmune diseases as well as in
animal models of autoimmune diseases. NKT cells recognize glycolipid antigens presented
by the nonpolymorphic MHC class I-like protein CD1d and participate in various kinds of
immunoregulation due to a potent ability to produce a variety of cytokines. In this review, we …
implicated in the regulation of autoimmunity. Abnormalities in the numbers and functions of
NKT cells have been observed in patients with diverse autoimmune diseases as well as in
animal models of autoimmune diseases. NKT cells recognize glycolipid antigens presented
by the nonpolymorphic MHC class I-like protein CD1d and participate in various kinds of
immunoregulation due to a potent ability to produce a variety of cytokines. In this review, we …
Abstract
CD1d-restricted invariant natural killer T (NKT) cells emerge as unique lymphocyte subsets implicated in the regulation of autoimmunity. Abnormalities in the numbers and functions of NKT cells have been observed in patients with diverse autoimmune diseases as well as in animal models of autoimmune diseases. NKT cells recognize glycolipid antigens presented by the nonpolymorphic MHC class I-like protein CD1d and participate in various kinds of immunoregulation due to a potent ability to produce a variety of cytokines. In this review, we examine the potential roles of NKT cells in the regulation and pathogenesis of autoimmune disease and the recent advances in glycolipid therapy for autoimmune disease models.
Springer
