Bone marrow–derived mesenchymal stem cells already express specific neural proteins before any differentiation
T Tondreau, L Lagneaux, M Dejeneffe, M Massy… - Differentiation, 2004 - Elsevier
Bone marrow mesenchymal stem cells (MSC) are multipotent cells. To explain their
plasticity, we postulated that undifferentiated MSC may express proteins from other tissues
such as neuronal tissues. MSC are obtained by two different approaches: plastic adhesion
or negative depletion (RosetteSep and magnetic beads CD45/glycophorin A). MSC are
evaluated through FACS analysis using a panel of antibodies (SH2, SH3, CD14, CD33,
CD34, CD45, etc.). To confirm the multipotentiality in vitro, we have differentiated MSC into …
plasticity, we postulated that undifferentiated MSC may express proteins from other tissues
such as neuronal tissues. MSC are obtained by two different approaches: plastic adhesion
or negative depletion (RosetteSep and magnetic beads CD45/glycophorin A). MSC are
evaluated through FACS analysis using a panel of antibodies (SH2, SH3, CD14, CD33,
CD34, CD45, etc.). To confirm the multipotentiality in vitro, we have differentiated MSC into …