Infantile hemangioma is a benign tumor of endothelial cells (ECs) that is well known to
pediatricians because of its frequency and sometimes disturbingly rapid growth. The primary
defect (s) that cause hemangioma have not yet been elucidated, but recent studies have
revealed that hemangiomas are composed of clonal ECs that exhibit abnormal properties in
vitro. These studies support the hypothesis that hemangiomas arise when a somatic
mutation occurs in a single endothelial progenitor, leading to dysregulated activity of one or …