Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis
DH Sikes, NM Agrawal, WW Zhao… - European journal of …, 2002 - journals.lww.com
Objective To determine whether valdecoxib, at chronic arthritis doses, has the characteristics
of a cyclo-oxygenase 2 (COX-2) specific inhibitor, as measured by a reduced incidence of
upper-gastrointestinal ulceration compared with conventional nonsteroidal anti-inflammatory
drugs (NSAIDs). Methods This double-blind, multicentre, placebo-controlled, parallel-group
study compared the incidence of gastroduodenal ulcers associated with valdecoxib 10 mg
daily (qd) and 20 mg qd with that of ibuprofen 800 mg three times daily (tid) or diclofenac 75 …
of a cyclo-oxygenase 2 (COX-2) specific inhibitor, as measured by a reduced incidence of
upper-gastrointestinal ulceration compared with conventional nonsteroidal anti-inflammatory
drugs (NSAIDs). Methods This double-blind, multicentre, placebo-controlled, parallel-group
study compared the incidence of gastroduodenal ulcers associated with valdecoxib 10 mg
daily (qd) and 20 mg qd with that of ibuprofen 800 mg three times daily (tid) or diclofenac 75 …
