Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model
RJ Lund, MR Davies, AJ Brown… - Journal of the American …, 2004 - journals.lww.com
An adynamic bone disorder (ABD) is an important complication of chronic kidney disease
(CKD) of unknown etiology for which there is no adequate treatment. Reported is an animal
model of ablative CKD complicated by an ABD characterized by the absence of secondary
hyperparathyroidism and its successful treatment with a skeletal anabolic factor, bone
morphogenetic protein-7 (BMP-7). Adult mice were subjected to electrocautery of the right
kidney followed by left nephrectomy. Animals were randomized into groups fed normal chow …
(CKD) of unknown etiology for which there is no adequate treatment. Reported is an animal
model of ablative CKD complicated by an ABD characterized by the absence of secondary
hyperparathyroidism and its successful treatment with a skeletal anabolic factor, bone
morphogenetic protein-7 (BMP-7). Adult mice were subjected to electrocautery of the right
kidney followed by left nephrectomy. Animals were randomized into groups fed normal chow …