Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome
MR Davies, RJ Lund, S Mathew… - Journal of the American …, 2005 - journals.lww.com
LDL receptor (LDLR)–null mice fed high-fat/cholesterol diets, a model of the metabolic
syndrome, have vascular calcification (VC) worsened by chronic kidney disease (CKD) and
ameliorated by bone morphogenetic protein-7 (BMP-7), an efficacious agent in treating
animal models of renal osteodystrophy. Here, LDLR−/− high-fat–fed mice without CKD were
shown to have significant reductions in bone formation rates, associated with increased VC
and hyperphosphatemia. Superimposing CKD resulted in a low turnover osteodystrophy …
syndrome, have vascular calcification (VC) worsened by chronic kidney disease (CKD) and
ameliorated by bone morphogenetic protein-7 (BMP-7), an efficacious agent in treating
animal models of renal osteodystrophy. Here, LDLR−/− high-fat–fed mice without CKD were
shown to have significant reductions in bone formation rates, associated with increased VC
and hyperphosphatemia. Superimposing CKD resulted in a low turnover osteodystrophy …