[HTML][HTML] Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A
T Hatanaka, W Huang, H Wang, M Sugawara… - … et Biophysica Acta (BBA …, 2000 - Elsevier
T Hatanaka, W Huang, H Wang, M Sugawara, PD Prasad, FH Leibach, V Ganapathy
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2000•ElsevierWe report here on the primary structure and functional characteristics of the protein
responsible for the system A amino acid transport activity that is known to be expressed in
most human tissues. This transporter, designated ATA2 for amino acid transporter A2, was
cloned from the human hepatoma cell line HepG2. Human ATA2 (hATA2) consists of 506
amino acids and exhibits a high degree of homology to rat ATA2. hATA2-specific mRNA is
ubiquitously expressed in human tissues. When expressed in mammalian cells, hATA2 …
responsible for the system A amino acid transport activity that is known to be expressed in
most human tissues. This transporter, designated ATA2 for amino acid transporter A2, was
cloned from the human hepatoma cell line HepG2. Human ATA2 (hATA2) consists of 506
amino acids and exhibits a high degree of homology to rat ATA2. hATA2-specific mRNA is
ubiquitously expressed in human tissues. When expressed in mammalian cells, hATA2 …
We report here on the primary structure and functional characteristics of the protein responsible for the system A amino acid transport activity that is known to be expressed in most human tissues. This transporter, designated ATA2 for amino acid transporter A2, was cloned from the human hepatoma cell line HepG2. Human ATA2 (hATA2) consists of 506 amino acids and exhibits a high degree of homology to rat ATA2. hATA2-specific mRNA is ubiquitously expressed in human tissues. When expressed in mammalian cells, hATA2 mediates Na+-dependent transport of α-(methylamino)isobutyric acid, a specific model substrate for system A. The transporter is specific for neutral amino acids. It is pH-sensitive and Li+-intolerant. The Na+:amino acid stoichiometry is 1:1.
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