Chemokines provide the sustained inflammatory bridge between innate and acquired immunity
AL Coelho, CM Hogaboam, SL Kunkel - Cytokine & growth factor reviews, 2005 - Elsevier
In this review we focus on the role of chemokines in discreet areas of innate immunity and
demonstrate that chemokines are key participants to not only the early inflammatory
response to a foreign agent, but important to the sustained immune reaction. Our studies
support the concept that a concerted and interactive innate and acquired immune reaction is
key for an automatic, dynamic, sustained, and regulated response toward clearing foreign
stimuli. It is imperative that the in vivo concept of innate and acquired immunity be …
demonstrate that chemokines are key participants to not only the early inflammatory
response to a foreign agent, but important to the sustained immune reaction. Our studies
support the concept that a concerted and interactive innate and acquired immune reaction is
key for an automatic, dynamic, sustained, and regulated response toward clearing foreign
stimuli. It is imperative that the in vivo concept of innate and acquired immunity be …