Altered distribution of basic fibroblast growth factor in diabetic retinopathy
A Hanneken, E de Juan, GA Lutty, GM Fox… - Archives of …, 1991 - jamanetwork.com
• Basic fibroblast growth factor (FGF) is a potent endothelial cell mitogen that has been
proposed to play a role in proliferative diabetic retinopathy and other neovascular
processes. Our understanding of the in vivo role of basic FGF in the pathogenesis of these
disorders is limited. We studied the immunolocalization of basic FGF in 16 clinical cases of
diabetic retinopathy to determine whether the normal retinal distribution of basic FGF
changed during the development of diabetic retinopathy and correlated with the onset of …
proposed to play a role in proliferative diabetic retinopathy and other neovascular
processes. Our understanding of the in vivo role of basic FGF in the pathogenesis of these
disorders is limited. We studied the immunolocalization of basic FGF in 16 clinical cases of
diabetic retinopathy to determine whether the normal retinal distribution of basic FGF
changed during the development of diabetic retinopathy and correlated with the onset of …
