The vast majority of diseases that cause catastrophic loss of vision do so as a result of ocular
neovascularization. During normal retinal vascular development, vascular endothelial cells
proliferate and migrate through the extracellular matrix in response to a variety of cytokines,
leading to the formation of new blood vessels in a highly ordered fashion. During abnormal
neovascularization of the iris, retina, or choroid, angiogenesis is unregulated and usually
results in the formation of dysfunctional blood vessels. When these newly formed vessels …