The nature of colitis in chronic granulomatous disease
MG Schäppi, NJ Klein, KJ Lindley… - Journal of pediatric …, 2003 - journals.lww.com
Background Patients with chronic granulomatous disease (CGD) may have gastrointestinal
manifestations, commonly colitis. The etiology, prevalence, and inflammatory process of
CGD colitis are unclear. Objectives To characterize the inflammatory process of CGD colitis
and to compare it with other inflammatory bowel disorders. Methods Colonic mucosal
biopsies from 8 CGD patients were immunostained for eosinophils, neutrophils,
macrophages, and adhesion molecules (ICAM; VCAM, E-selectin) and compared with …
manifestations, commonly colitis. The etiology, prevalence, and inflammatory process of
CGD colitis are unclear. Objectives To characterize the inflammatory process of CGD colitis
and to compare it with other inflammatory bowel disorders. Methods Colonic mucosal
biopsies from 8 CGD patients were immunostained for eosinophils, neutrophils,
macrophages, and adhesion molecules (ICAM; VCAM, E-selectin) and compared with …
Colitis in chronic granulomatous disease
MG Schäppi, VV Smith, D Goldblatt… - Archives of disease in …, 2001 - adc.bmj.com
BACKGROUND Involvement of the gut in chronic granulomatous disease (CGD) has been
previously described and colitis highlighted. However, the nature and histopathology of the
colitis are unclear and have been thought to be non-specific or similar to Crohn's disease.
METHODS Seven patients with CGD, suffering from gastrointestinal symptoms were
prospectively studied. RESULTS All patients had anaemia; other symptoms were failure to
thrive (5/7) and diarrhoea (5/7). Most had microcytic anaemia (5/7), increased platelets (7/7) …
previously described and colitis highlighted. However, the nature and histopathology of the
colitis are unclear and have been thought to be non-specific or similar to Crohn's disease.
METHODS Seven patients with CGD, suffering from gastrointestinal symptoms were
prospectively studied. RESULTS All patients had anaemia; other symptoms were failure to
thrive (5/7) and diarrhoea (5/7). Most had microcytic anaemia (5/7), increased platelets (7/7) …
