We present a novel animal model for post-transplant obliterative airway disease in which the
donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is
technically more challenging than the heterotopic model of implantation into a subcutaneous
pouch, it has several important advantages some of which are the appropriate local
environment and the possibility of local immunosuppressive therapy after transtracheal
gene, cell or drug delivery. This model has revealed new insights into angiogenic potential …