Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2
J Heidemann, H Ogawa, MB Dwinell, P Rafiee… - Journal of Biological …, 2003 - ASBMB
Angiogenesis plays a critical role in metastasis and tumor growth. Human tumors, including
colorectal adenocarcinoma, secrete angiogenic factors, inducing proliferation and
chemotaxis of microvascular endothelial cells, eventually leading to tumor
neovascularization. The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic
properties on endothelial cells through interaction with its cognate receptors CXCR1 and
CXCR2. As CXCR1 and CXCR2 expression is differentially regulated in tissue-specific …
colorectal adenocarcinoma, secrete angiogenic factors, inducing proliferation and
chemotaxis of microvascular endothelial cells, eventually leading to tumor
neovascularization. The chemokine interleukin 8 (IL-8; CXCL8) exerts potent angiogenic
properties on endothelial cells through interaction with its cognate receptors CXCR1 and
CXCR2. As CXCR1 and CXCR2 expression is differentially regulated in tissue-specific …
