CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and
mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC
chemokines are a unique family of cytokines, known for their ability to behave in a disparate
manner in the regulation of angiogenesis. Members that contain the 'ELR'motif are potent
promoters of angiogenesis, and mediate their angiogenic activity via binding and activating
CXCR2 on endothelium. In contrast, members, in general, those are inducible by interferons …