Chaperones get in touch: the Hip-Hop connection
J Frydman, J Höhfeld - Trends in biochemical sciences, 1997 - cell.com
J Frydman, J Höhfeld
Trends in biochemical sciences, 1997•cell.comRecent findings emphasize that different molecular chaperones cooperate during
intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now
emerging from studies on the regulation of certain signal transduction pathways mediated by
Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved
through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.
intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now
emerging from studies on the regulation of certain signal transduction pathways mediated by
Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved
through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.
Abstract
Recent findings emphasize that different molecular chaperones cooperate during intracellular protein biogenesis. Mechanistic aspects of chaperone cooperation are now emerging from studies on the regulation of certain signal transduction pathways mediated by Hsc70 and Hsp90 in the eukaryotic cytosol. Efficient cooperation appears to be achieved through a defined regulation of Hsc70 activity by the chaperone cofactors Hip and Hop.
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