Intense pain or intense peripheral inflammation experienced during development can have
pronounced effects upon adult pain sensation. However, little is known about the more
commonly encountered mild systemic inflammation, such as that experienced with mild
illness. Neonatal exposure to lipopolysaccharide (LPS), an established model of immune
system activation, has been shown to affect febrile and cyclooxygenase-2 (COX-2)
responses to a similar exposure in adulthood. Adult LPS also elicits a range of sickness …