Oncogenic PI3K and its role in cancer
Y Samuels, K Ericson - Current opinion in oncology, 2006 - journals.lww.com
Y Samuels, K Ericson
Current opinion in oncology, 2006•journals.lww.comThe PI3K signaling pathway is dysregulated by a variety of mechanisms in a large fraction of
human tumors. Both mutational and functional analyses have shown that PIK3CA is an
oncogene that plays an important role in tumor progression. Mutant members of the PI3K
pathway, including PIK3CA, are good targets for therapeutic intervention because most of
them are kinases, making them attractive for drug development. Gaining further insights into
PIK3CA oncogenic mechanisms may produce new biomarkers and help the development of …
human tumors. Both mutational and functional analyses have shown that PIK3CA is an
oncogene that plays an important role in tumor progression. Mutant members of the PI3K
pathway, including PIK3CA, are good targets for therapeutic intervention because most of
them are kinases, making them attractive for drug development. Gaining further insights into
PIK3CA oncogenic mechanisms may produce new biomarkers and help the development of …
Summary
The PI3K signaling pathway is dysregulated by a variety of mechanisms in a large fraction of human tumors. Both mutational and functional analyses have shown that PIK3CA is an oncogene that plays an important role in tumor progression. Mutant members of the PI3K pathway, including PIK3CA, are good targets for therapeutic intervention because most of them are kinases, making them attractive for drug development. Gaining further insights into PIK3CA oncogenic mechanisms may produce new biomarkers and help the development of targeted therapeutics.
Lippincott Williams & Wilkins