[PDF][PDF] CFTR nonsense mutations G542X and W1282X associated with severe reduction of CFTR mRNA in nasal epithelial cells
A Hamosh, BJ Rosenstein… - Human molecular …, 1992 - oxfordjournals.org
A Hamosh, BJ Rosenstein, GR Cutting
Human molecular genetics, 1992•oxfordjournals.orgFigure la. 32P-labelled ASO hybridization to PCR amplified DNA from genomic DNA or
cDNA from CFTR exons 7-11. The ASOs are as indicated; the dots are in duplicate, lb. 32P-
labelled ASO hybridization to PCR amplified DNA from genomic DNA or cDNA from CFTR
exons 18-24. The ASOs are as indicated; the dots are in duplicate. The W1282X/AF508
cDNA is derived from a nasal polyp cell culture; the AF508/unknown cDNA is derived from a
tracheal cell culture.
cDNA from CFTR exons 7-11. The ASOs are as indicated; the dots are in duplicate, lb. 32P-
labelled ASO hybridization to PCR amplified DNA from genomic DNA or cDNA from CFTR
exons 18-24. The ASOs are as indicated; the dots are in duplicate. The W1282X/AF508
cDNA is derived from a nasal polyp cell culture; the AF508/unknown cDNA is derived from a
tracheal cell culture.
Figure la. 32P-labelled ASO hybridization to PCR amplified DNA from genomic DNA or cDNA from CFTR exons 7-11. The ASOs are as indicated; the dots are in duplicate, lb. 32P-labelled ASO hybridization to PCR amplified DNA from genomic DNA or cDNA from CFTR exons 18-24. The ASOs are as indicated; the dots are in duplicate. The W1282X/AF508 cDNA is derived from a nasal polyp cell culture; the AF508/unknown cDNA is derived from a tracheal cell culture.
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