[HTML][HTML] Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt-and MEK1/ERK-dependent …
J Gu, A Fujibayashi, KM Yamada… - Journal of Biological …, 2002 - ASBMB
Cell adhesion to the extracellular matrix inhibits apoptosis, but the molecular mechanisms
underlying the signals transduced by different matrix components are not well understood.
Here, we examined integrin-mediated antiapoptotic signals from laminin-10/11 in
comparison with those from fibronectin, the best characterized extracellular adhesive ligand.
We found that the activation of protein kinase B/Akt in cells adhering to laminin-10/11 can
rescue cell apoptosis induced by serum removal. Consistent with this, wortmannin, a specific …
underlying the signals transduced by different matrix components are not well understood.
Here, we examined integrin-mediated antiapoptotic signals from laminin-10/11 in
comparison with those from fibronectin, the best characterized extracellular adhesive ligand.
We found that the activation of protein kinase B/Akt in cells adhering to laminin-10/11 can
rescue cell apoptosis induced by serum removal. Consistent with this, wortmannin, a specific …