High-density lipoproteins as an emerging therapeutic target for atherosclerosis
DJ Rader - Jama, 2003 - jamanetwork.com
PLASMA LEVELS OF HIGH-DENSITY LIPOPROTEIN CHO-lesterol (HDL-C) and its major
protein apolipopro-tein AI (apoA-I) are consistently inversely associated with coronary heart
disease (CHD) risk in observational studies. 1 Furthermore, studies in animals over the last
2 decades have established that intravenous infusion of HDL or apoA-I or genetic
overexpression of apoA-I can substantially reduce the progression and even induce
regression of preexisting atherosclerosis. 2 Based on these data, HDL and apoA-I have …
protein apolipopro-tein AI (apoA-I) are consistently inversely associated with coronary heart
disease (CHD) risk in observational studies. 1 Furthermore, studies in animals over the last
2 decades have established that intravenous infusion of HDL or apoA-I or genetic
overexpression of apoA-I can substantially reduce the progression and even induce
regression of preexisting atherosclerosis. 2 Based on these data, HDL and apoA-I have …
