Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing–remitting demyelinating disease in NOD mice induced with myelin …
M Ichikawa, CS Koh, A Inoue, J Tsuyusaki… - Journal of …, 2000 - Elsevier
Treatment with monoclonal anti-IL-12 antibody injected on day 0, 7 and 10 after
immunization with myelin oligodendrocyte glycoprotein (MOG) peptide 35–55 in NOD mice
resulted in significant suppression of the development and the severity of the chronic
relapsing–remitting experimental autoimmune encephalomyelitis (EAE) both clinically and
histologically. The spleen cells from anti-IL-12 antibody treated mice displayed markedly
inhibited MOG35–55 specific proliferation and IFN-γ production. MOG35–55 specific …
immunization with myelin oligodendrocyte glycoprotein (MOG) peptide 35–55 in NOD mice
resulted in significant suppression of the development and the severity of the chronic
relapsing–remitting experimental autoimmune encephalomyelitis (EAE) both clinically and
histologically. The spleen cells from anti-IL-12 antibody treated mice displayed markedly
inhibited MOG35–55 specific proliferation and IFN-γ production. MOG35–55 specific …
