[42] Cytochrome P450 arachidonic acid epoxygenase: Stereochemical characterization of epoxyeicosatrienoic acids
JH Capdevila, E Dishman, A Karara, JR Falck - Methods in enzymology, 1991 - Elsevier
Publisher Summary This chapter discusses the cytochrome P450 arachidonic acid
epoxygenase. The epoxygenase regio-and stereoselectivity of oxygenation is under the
control of the cytochrome P450 protein catalyst. The potential functional significance of this
metabolic pathway has been highlighted by (a) the potent biological activities of the
epoxyeicosatrienoic acids (EETs), and (b) the demonstration of a role for the hemoprotein in
the in vivo metabolism of endogenous arachidonic acid. The enantioselective nature of the …
epoxygenase. The epoxygenase regio-and stereoselectivity of oxygenation is under the
control of the cytochrome P450 protein catalyst. The potential functional significance of this
metabolic pathway has been highlighted by (a) the potent biological activities of the
epoxyeicosatrienoic acids (EETs), and (b) the demonstration of a role for the hemoprotein in
the in vivo metabolism of endogenous arachidonic acid. The enantioselective nature of the …
