Impaired glucose homeostasis in mice lacking the α1b-adrenergic receptor subtype
R Burcelin, M Uldry, M Foretz, C Perrin… - Journal of Biological …, 2004 - ASBMB
To assess the role of the α 1b-adrenergic receptor (AR) in glucose homeostasis, we
investigated glucose metabolism in knockout mice deficient of this receptor subtype (α 1b-
AR-/-). Mutant mice had normal blood glucose and insulin levels, but elevated leptin
concentrations in the fed state. During the transition to fasting, glucose and insulin blood
concentrations remained markedly elevated for at least 6 h and returned to control levels
after 24 h whereas leptin levels remained high at all times. Hyperinsulinemia in the post …
investigated glucose metabolism in knockout mice deficient of this receptor subtype (α 1b-
AR-/-). Mutant mice had normal blood glucose and insulin levels, but elevated leptin
concentrations in the fed state. During the transition to fasting, glucose and insulin blood
concentrations remained markedly elevated for at least 6 h and returned to control levels
after 24 h whereas leptin levels remained high at all times. Hyperinsulinemia in the post …
