Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
A Krueger, I Schmitz, S Baumann, PH Krammer… - Journal of Biological …, 2001 - ASBMB
Upon stimulation, CD95 (APO-1/Fas) recruits the adapter molecule FADD/MORT1,
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing
signaling complex (DISC). According to the induced proximity model, procaspase-8 is
activated in the DISC in an autoproteolytic manner by two subsequent cleavage steps. c-
FLIP proteins exist as a long (c-FLIP L) and a short (c-FLIP S) splice variant, both of them
capable of protecting cells from death receptor-mediated apoptosis. In stably transfected …
procaspase-8, and the cellular FLICE-inhibitory proteins (c-FLIP) into the death-inducing
signaling complex (DISC). According to the induced proximity model, procaspase-8 is
activated in the DISC in an autoproteolytic manner by two subsequent cleavage steps. c-
FLIP proteins exist as a long (c-FLIP L) and a short (c-FLIP S) splice variant, both of them
capable of protecting cells from death receptor-mediated apoptosis. In stably transfected …
