[HTML][HTML] Oxidation of cholesterol by amyloid precursor protein and β-amyloid peptide
TJ Nelson, DL Alkon - Journal of Biological Chemistry, 2005 - ASBMB
Alzheimer's disease (AD) is characterized by accumulation of the neurotoxic peptide β-
amyloid, which is produced by proteolysis of amyloid precursor protein (APP). APP is a large
membrane-bound copper-binding protein that is essential in maintaining synaptic function
and may play a role in synaptogenesis. β-Amyloid has been shown to contribute to the
oxidative stress that accompanies AD. Later stages of AD are characterized by neuronal
apoptosis. However, the biochemical function of APP and the mechanism of the toxicity of β …
amyloid, which is produced by proteolysis of amyloid precursor protein (APP). APP is a large
membrane-bound copper-binding protein that is essential in maintaining synaptic function
and may play a role in synaptogenesis. β-Amyloid has been shown to contribute to the
oxidative stress that accompanies AD. Later stages of AD are characterized by neuronal
apoptosis. However, the biochemical function of APP and the mechanism of the toxicity of β …
