Genetically modified mouse models for pharmacogenomic research
SB Liggett - Nature Reviews Genetics, 2004 - nature.com
SB Liggett
Nature Reviews Genetics, 2004•nature.comIt is now evident that differences in the DNA sequence of genes involved with drug action
can lead to interindividual differences in effectiveness and adverse reactions to therapeutic
drugs. Pharmacogenomics raises the possibility that drug discovery and patient
management could move from a'one drug fits all'approach to one in which therapy is tailored
to patients' genomes. Genetically modified mice that mimic human variation in drug
response can provide one of the tools to move the field towards these goals.
can lead to interindividual differences in effectiveness and adverse reactions to therapeutic
drugs. Pharmacogenomics raises the possibility that drug discovery and patient
management could move from a'one drug fits all'approach to one in which therapy is tailored
to patients' genomes. Genetically modified mice that mimic human variation in drug
response can provide one of the tools to move the field towards these goals.
Abstract
It is now evident that differences in the DNA sequence of genes involved with drug action can lead to interindividual differences in effectiveness and adverse reactions to therapeutic drugs. Pharmacogenomics raises the possibility that drug discovery and patient management could move from a 'one drug fits all' approach to one in which therapy is tailored to patients' genomes. Genetically modified mice that mimic human variation in drug response can provide one of the tools to move the field towards these goals.
nature.com
