Gestational diabetogenesis: quantitative analyses of glucose-insulin interrelationship between normal pregnancy and pregnancy with gestational diabetes

SSC Yen, CC Tsai, P Vela - American Journal of Obstetrics and …, 1971 - Elsevier
The interrelationship between insulin (IRI) and glucose in response to rapid intravenous
glucose challenge (IVGTT) was assessed in 14 patients with gestational diabetes during
pregnancy and at 6 to 8 weeks post partum. Comparison of the quantitative changes with
sequential data obtained in nondiabetic subjects during pregnancy was made. Our data
show that in gestational diabetes the development of hyperglycemia and retardation of
glucose disposition (K) is associated with a significant increase in the glucose pool. These …