Absence of H (+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis.
EP Cohen, B Bastani, MR Cohen… - Journal of the …, 1992 - journals.lww.com
Distal urinary acidification abnormalities may arise from transepithelial voltage defects,
permeability defects, or proton-secretory defects, but tests to determine the cellular
mechanisms underlying secretory abnormalities have not previously been reported. A
patient with Sjogren's syndrome and distal renal tubular acidosis due to a secretory defect is
described, whose kidney biopsy was examined by fluorescent immunocytochemistry with an
antibody to the M (r) 31,000 subunit of the mammalian kidney vacuolar H (+)-ATPase and …
permeability defects, or proton-secretory defects, but tests to determine the cellular
mechanisms underlying secretory abnormalities have not previously been reported. A
patient with Sjogren's syndrome and distal renal tubular acidosis due to a secretory defect is
described, whose kidney biopsy was examined by fluorescent immunocytochemistry with an
antibody to the M (r) 31,000 subunit of the mammalian kidney vacuolar H (+)-ATPase and …